Transfusion Support

Lasix Dose for TACO Prevention

Estimate 6-hour urine output and derive a Lasix dose from the 2025 Vox Sanguinis dose-response study.

Admin

Sex

Chronic diuretic use

Weight units

Live result

Recommended Lasix dose

1.07 mg

Recommended dose / kg

0.02 mg/kg

Predicted urine output at 6 h

859.9 mL

Entered dose / kg

0.29 mg/kg

The entered dose predicts a 6-hour urine output using the published dose-response equation. The recommended dose is the inverse of that same equation for the target urine output you enter.

Formula detail

Urine output at 6 h (mL) = 717.21 + 191.33 ln(dose/weight) + 0.73 x age + 103.37 x sex + 1.63 x GFR + 5.45 x MAP - 9.56 x albumin - 62.31 x diuretic history.

Sex is scored as 1 for male and 0 for female. Diuretic history is scored as 1 for yes and 0 for no.

Source

Rotin L, Zhang L, Armali C, Malkin A, Massin S, Meirovich H, Roque D, Saeed S, Vijenthira S, Lin Y, Pendergrast J. How much furosemide should be administered to prevent transfusion-associated circulatory overload? Results of a dose-finding study. Vox Sang. 2025 Jul;120(7):683-693. PubMed